Multiple sclerosis (MS)

Overview

What is multiple sclerosis

Multiple sclerosis (MS) is an autoimmune disorder affecting the central nervous system. The immune system attacks the nerves of the brain and spinal cord. Body movements may become slow or uncoordinated because signals from the brain to the muscles deteriorate, or arms and legs may feel numb because sensations from the extremities no longer reach the brain. The condition becomes progressively worse over time if not effectively treated. Although there is no cure, medications can help reduce inflammation and lengthen periods between attacks.1, 2

How common is multiple sclerosis

There are about 400,000 people in the U.S. living with MS. The condition is typically diagnosed anywhere from age 20 to age 50.3 Certain populations have an increased risk of developing MS. Whites are more than twice as likely as other races to develop MS, and women are affected almost twice as often as men.
Geography and climate may also impact an individual’s MS risk factor. MS is five times more prevalent in the northern United States, Canada, and Europe than in tropical regions.4, 5, 6, 7, 8


Questions regarding your multiple sclerosis therapy

You can reach the Accredo MS care team, anytime, day or night, seven days a week.

24-hour Customer Service Center

800-803-2523

  • 1

    The Basic Facts: The History of MS. Rolak et al. The National Multiple Sclerosis Society, 2013; www.nationalmssociety.org NINDS Multiple Sclerosis Information Page. The National Institute of Neurological Disorders and Stroke, National Institutes of Health. October, 2004.

  • 2

    Multiple Sclerosis: Hope Through Research. The National Institute of Neurological Disorders and Stroke, National Institutes of Health. July, 2004. www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Hope-Through-Research/Multiple-Sclerosis-Hope-Through-Research

  • 3Halper J, Holland N. Comprehensive Nursing Care In Multiple Sclerosis, 2nd ed. Ney York: Demos; 2002.
  • 4Dangond, F. Multiple Sclerosis. eMedicine.com. July, 2004.>Capturing and Classifying Functional Status Information in Administrative Databases. The Centers for Medicare & Medicaid Services (CMS), The Centers for Medicare & Medicaid Services (CMS)
  • 5Bates, B. A Guide to Physical Examination and History Taking, Fifth Edition. Philadelphia: J.B. Lippincott Company; 1991.
  • 6McCance K, Huether S. Pathophysiology: The Biologic Basis for Diseases in Adults and Children, Fourth Edition. St. Louis: Mosby; 1994.
  • 7Lewis S, Collier I. Medical Surgical Nursing: Assessment and Management of Clinical Problems, Third Edition. St. Louis: Mosby; 1992.
  • 8

    About MS: Diagnosing MS. The National MS Society. Accessed 11_25_13. www.nationalmssociety.org/Symptoms-Diagnosis

Symptoms

What are the symptoms of multiple sclerosis

Most people experience their first symptoms of MS between the ages of 20 and 40. While symptoms rarely begin before age 15 or after age 60, scientists have documented the initial symptoms of MS at almost every age.1 When symptoms occur, they can include:

  • Dizziness, blurred or double vision
  • Muscle weakness in the arms and legs
  • Difficulty with coordination and balance
  • Muscle stiffness and spasms
  • Numbness, prickling or tingling sensations
  • Difficulty with concentration, attention span and memory
  • Fatigue
  • Speech impediments
  • Tremors

How is it diagnosed

Unfortunately, there is no clear combination of symptoms or test results that can definitively say a person has MS. Health care providers use an array of testing strategies to determine if a person meets the criteria for a diagnosis of MS, including ruling out other possible causes of symptoms. Doctors will typically take a detailed past medical history, including detailed descriptions of symptoms and when they started. Then a physical and neurologic exam will be performed including a panel of imaging tests, such as magnetic resonance imaging (MRI). Typically, no one test is enough to confirm the presence of MS; a combination of positive findings is required.2

Physicians often use the Revised McDonald Criteria in order to make a more efficient diagnosis of MS.3

Other neurologic tests that may be completed are MRI, Visual Evoked Potential (VEP), and Cerebrospinal Fluid Analysis.4

  • 1Bates, B. A Guide to Physical Examination and History Taking, Fifth Edition. Philadelphia: J.B. Lippincott Company; 1991.
  • 2McCance K, Huether S. Pathophysiology: The Biologic Basis for Diseases in Adults and Children, Fourth Edition. St. Louis: Mosby; 1994.
  • 3Lewis S, Collier I. Medical Surgical Nursing: Assessment and Management of Clinical Problems, Third Edition. St. Louis: Mosby; 1992.
  • 4

    About MS: Diagnosing MS. The National MS Society. Accessed 11_25_13. www.nationalmssociety.org/Symptoms-Diagnosis

Medications

Multiple sclerosis

The following specialty medications are available at Accredo, a specialty pharmacy for multiple sclerosis.

Medication Manufacturer
Ampyra® (dalfampridine) Acorda Therapeutics, Inc.
Aubagio® (teriflunomide) Genzyme Corporation
Avonex® (interferon beta_1a) Biogen, Inc.
Bafiertam™ (monomethyl fumarate) Banner Life Sciences
Betaseron® (interferon beta-1b) Bayer, Pharm Div.
Briumvi™ (ublituximab-xiiy) TG Therapeutics, Inc.
Copaxone® (glatiramer acetate) Teva Neuroscience, Inc.
Gilenya® (fingolimod) Novartis Pharmaceuticals Corp.
Glatopa® (glatiramer acetate) Sandoz Pharmaceuticals, Inc.
Lemtrada® (alemtuzumab) Genzyme Corporation
Mavenclad® (cladribine) EMD Serono, Inc.
Mayzent® (Siponimod) Novartis Pharmaceuticals Corp.
Ocrevus™ (ocrelizumab) Genentech USA, Inc.
Plegridy® (peginterferon beta-1a) Biogen, Inc.
Rebif® (interferon beta_1a) EMD Serono, Inc.
Tascenso ODT® (fingolimod) Cycle Vita
Tecfidera® (dimethyl fumarate) Biogen, Inc.
Tysabri® (natalizumab) Biogen, Inc.
Uplizna® (inebilizumab injection) Horizon Therapeutics, plc
Vumerity™ (diroximel fumarate) Biogen, Inc.
Zeposia® (ozanimod) Bristol-Myers Squibb Company

Financing Your Care

Financial resources are available to support your drug costs, including manufacturer and community programs. You may also use the copay assistance search for additional programs. Accredo specialists are available to help you find the right program for you.


Financial Guidance

Life-saving specialty medication can be expensive. Learn how the Accredo teams help individuals find ways to afford the medication they need to survive in this video.

Find Support

There are many organizations that support research and advocacy for MS. See below for a few of those organizations.

Support organizations

Meet the Team

Accredo’s MS care team is dedicated to serving you and we understand the complexity of your condition. Our specialty-trained clinicians are available 24 hours a day, seven days a week, to answer any questions.

Why We Do It

Accredo supports patients with chronic and complex conditions and helps them live their best life. Watch our video to learn why we do what we do for our patients.

Why We Do It video transcript

24-hour Customer Service Center

800-803-2523